Pharmacogenetics and Warfarin Dosing: Has the Time Come for Routine Application?
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The time has come.
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This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence from the published literature is presented for CYP2C9, VKORC1, CYP4F2, and rs12777823 genotype-guided warfarin dosing to achieve a target international normalized ratio of 2-3 when clinical genotype results are available. In ad...
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BACKGROUND AND AIM Warfarin is the most frequently prescribed anticoagulant worldwide. However, warfarin therapy is associated with a high risk of bleeding and thromboembolic events because of a large interindividual dose-response variability. We investigated the effect of genetic and non genetic factors on warfarin dosage in a South Italian population in the attempt to setup an algorithm easil...
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The study of spin glasses is perceived by some as hard, controversial, and useless. As a result, its fundamentals are often relegated to end-of-semester topics, prefaced by forewarnings, and surrounded by scare quotes. That is, when they are mentioned at all. Yet the last three decades have repeatedly evinced that archetypical glassy systems, such as the random energy model, the perceptron and ...
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2007
ISSN: 0018-5787,1945-1253
DOI: 10.1310/hpj4201-9